For the hundreds of thousands of people that take Ozempic and Wegovy, weight loss is the best-known consequence — however a brand new examine suggests the medicines may additionally assist squash melancholy.
Investigators from Epic Analysis, a well being analytics agency based mostly in Verona, Wisconsin, discovered that patients with diabetes who had been prescribed glucagon-like peptide-1 receptor agonist (GLP-1) medicines had been much less prone to develop melancholy in comparison with people who find themselves not taking the medicine.
GLP-1 medicines embrace semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon).
“The probability of tension in diabetic sufferers is decrease for these on all 5 GLP-1 medicines studied,” the researchers wrote in a launch on Epic’s web site.
For these with out diabetes, semaglutide was linked to a decrease probability of melancholy and anxiousness, whereas liraglutide didn’t present any statistically important profit.
![Happy woman weight loss](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/happy-woman-mirror-weight-loss.jpg?ve=1&tl=1)
Weight reduction is the best-known perk of Ozempic and Wegovy, however a brand new examine suggests the medicines may additionally assist to cut back melancholy. (iStock)
The examine analyzed the GLP-1 medicines and mental health diagnoses of three,081,254 diabetic sufferers and 929,174 non-diabetic sufferers.
Dr. Brett Osborn, a Florida neurologist and founding father of the longevity firm Senolytix, was not stunned to listen to of the Epic Analysis examine findings.
“Ozempic’s potential antidepressive effects are garnering curiosity, each from the scientific neighborhood and people searching for holistic methods to handle their psychological well being alongside bodily situations,” he advised Fox Information Digital.
Weight reduction usually results in a lift in temper and general outlook in Osborn’s sufferers, he famous.
![Ozempic](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/ozempic.jpg?ve=1&tl=1)
GLP-1 medicines embrace semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon). (Getty Pictures)
“Shedding pounds can considerably influence a person’s shallowness and general temper, resulting in a extra constructive outlook on life,” the physician stated.
“The boldness increase that comes with reaching weight reduction targets may be transformative, decreasing emotions of melancholy and enhancing psychological well-being.”
OZEMPIC AND WEGOVY COULD LEAD TO MUSCLE LOSS, EXPERTS SAY, BUT PREVENTION IS POSSIBLE
Dr. Jennifer Bourgeois, PharmD, a Dallas-based pharmacy and health expert with SingleCare, a prescription low cost service, stated not one of the corporations that produce GLP-1 medicines studied the impact on melancholy within the unique medical trials.
“At the moment, not one of the GLP-1 medicines used to enhance glycemic management in adults with kind 2 diabetes or in power weight administration declare to curb melancholy and anxiousness,” she advised Fox Information Digital.
That doesn’t imply it’s not attainable, nevertheless, the knowledgeable stated.
Bodily and psychological mood-lifters
In earlier analysis, Ozempic and different GLP-1 medicine had been proven to have antidepressant-like results in diabetic mice with type 2 diabetes, suggesting that the medicine have direct results on mind chemistry and connectivity, Osborn stated.
“It’s thought that this outcomes from GLP-1’s affect on the discharge of neurotransmitters, comparable to norepinephrine and serotonin, in a deep mind area often called the hypothalamus,” Osborn stated.
![Man healthy food](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/man-healthy-food.jpg?ve=1&tl=1)
Weight reduction usually leads individuals to undertake more healthy life-style habits, comparable to common train and improved dietary selections, an knowledgeable identified. (iStock)
GLP-1 medicine additionally modify the discharge of dopamine within the amygdala, the “emotional middle” of the mind, Osborn stated, which is concerned in temper regulation.
Whereas Bourgeois agrees that these medicines might influence temper through mind modifications, she stated the likelier cause for the decreased melancholy and anxiousness is the constructive psychological and bodily health effects of weight reduction.
OZEMPIC AND WEGOVY WEIGHT LOSS DRUGS COULD HELP REDUCE ALCOHOL USE DISORDER SYMPTOMS, STUDY SUGGESTS
Weight reduction induced by GLP-1 medicines triggers organic modifications that positively influence temper regulation, Bourgeois stated.
“As extra adipose tissue (physique fats) decreases, the manufacturing of inflammatory cytokines reduces, resulting in a lower in systemic irritation,” she stated.
“Analysis means that power irritation might disrupt neurotransmitters like serotonin and dopamine in addition to the steadiness of intestine micro organism, probably resulting in temper imbalances.”
![Mounjaro](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/mounjaro.jpg?ve=1&tl=1)
A pharmacist holds containers of Eli Lilly & Co. Mounjaro model tirzepatide treatment at a pharmacy in Provo, Utah, on Monday, Nov. 27, 2023. (Getty Pictures)
The increase to shallowness and physique picture also can curb melancholy and anxiousness, Bourgeois famous, resulting in an general extra constructive outlook.
“People who obtain weight reduction by means of GLP-1 receptor agonists might expertise a way of accomplishment and empowerment, which might positively affect their psychological well being,” she stated.
CLICK HERE TO GET THE FOX NEWS APP
There may additionally be a “trickle-down” impact, with weight reduction usually main individuals to undertake healthier lifestyle habits — comparable to common train and improved dietary selections, the knowledgeable identified.
“These life-style modifications can have profound results on psychological well being,” she stated.
![Woman scale](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/woman-scale.jpg?ve=1&tl=1)
The increase to shallowness and physique picture that comes with weight reduction also can curb melancholy and anxiousness, specialists say. (iStock)
“Bodily exercise is thought to stimulate the discharge of endorphins, which promote emotions of happiness and euphoria, and a nutrient-rich diet can present important nutritional vitamins and minerals that help mind perform and temper regulation.”
Extra analysis wanted
Whereas the Epic knowledge is “promising,” stated Bourgeois, “extra analysis is required to find out if the treatment itself is accountable for the discount in melancholy and anxiousness diagnoses.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Different components like bodily exercise, weight loss plan and sleep weren’t managed and could possibly be contributing to the mood-altering results.”
Osborn added, “I’m not saying that Ozempic will turn out to be a first-line therapy for melancholy, however it actually highlights the interconnectedness of bodily and psychological well being.”
For more Health articles, visit www.foxnews.com/health.
For the hundreds of thousands of people that take Ozempic and Wegovy, weight loss is the best-known consequence — however a brand new examine suggests the medicines may additionally assist squash melancholy.
Investigators from Epic Analysis, a well being analytics agency based mostly in Verona, Wisconsin, discovered that patients with diabetes who had been prescribed glucagon-like peptide-1 receptor agonist (GLP-1) medicines had been much less prone to develop melancholy in comparison with people who find themselves not taking the medicine.
GLP-1 medicines embrace semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon).
“The probability of tension in diabetic sufferers is decrease for these on all 5 GLP-1 medicines studied,” the researchers wrote in a launch on Epic’s web site.
For these with out diabetes, semaglutide was linked to a decrease probability of melancholy and anxiousness, whereas liraglutide didn’t present any statistically important profit.
![Happy woman weight loss](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/happy-woman-mirror-weight-loss.jpg?ve=1&tl=1)
Weight reduction is the best-known perk of Ozempic and Wegovy, however a brand new examine suggests the medicines may additionally assist to cut back melancholy. (iStock)
The examine analyzed the GLP-1 medicines and mental health diagnoses of three,081,254 diabetic sufferers and 929,174 non-diabetic sufferers.
Dr. Brett Osborn, a Florida neurologist and founding father of the longevity firm Senolytix, was not stunned to listen to of the Epic Analysis examine findings.
“Ozempic’s potential antidepressive effects are garnering curiosity, each from the scientific neighborhood and people searching for holistic methods to handle their psychological well being alongside bodily situations,” he advised Fox Information Digital.
Weight reduction usually results in a lift in temper and general outlook in Osborn’s sufferers, he famous.
![Ozempic](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/ozempic.jpg?ve=1&tl=1)
GLP-1 medicines embrace semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon). (Getty Pictures)
“Shedding pounds can considerably influence a person’s shallowness and general temper, resulting in a extra constructive outlook on life,” the physician stated.
“The boldness increase that comes with reaching weight reduction targets may be transformative, decreasing emotions of melancholy and enhancing psychological well-being.”
OZEMPIC AND WEGOVY COULD LEAD TO MUSCLE LOSS, EXPERTS SAY, BUT PREVENTION IS POSSIBLE
Dr. Jennifer Bourgeois, PharmD, a Dallas-based pharmacy and health expert with SingleCare, a prescription low cost service, stated not one of the corporations that produce GLP-1 medicines studied the impact on melancholy within the unique medical trials.
“At the moment, not one of the GLP-1 medicines used to enhance glycemic management in adults with kind 2 diabetes or in power weight administration declare to curb melancholy and anxiousness,” she advised Fox Information Digital.
That doesn’t imply it’s not attainable, nevertheless, the knowledgeable stated.
Bodily and psychological mood-lifters
In earlier analysis, Ozempic and different GLP-1 medicine had been proven to have antidepressant-like results in diabetic mice with type 2 diabetes, suggesting that the medicine have direct results on mind chemistry and connectivity, Osborn stated.
“It’s thought that this outcomes from GLP-1’s affect on the discharge of neurotransmitters, comparable to norepinephrine and serotonin, in a deep mind area often called the hypothalamus,” Osborn stated.
![Man healthy food](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/man-healthy-food.jpg?ve=1&tl=1)
Weight reduction usually leads individuals to undertake more healthy life-style habits, comparable to common train and improved dietary selections, an knowledgeable identified. (iStock)
GLP-1 medicine additionally modify the discharge of dopamine within the amygdala, the “emotional middle” of the mind, Osborn stated, which is concerned in temper regulation.
Whereas Bourgeois agrees that these medicines might influence temper through mind modifications, she stated the likelier cause for the decreased melancholy and anxiousness is the constructive psychological and bodily health effects of weight reduction.
OZEMPIC AND WEGOVY WEIGHT LOSS DRUGS COULD HELP REDUCE ALCOHOL USE DISORDER SYMPTOMS, STUDY SUGGESTS
Weight reduction induced by GLP-1 medicines triggers organic modifications that positively influence temper regulation, Bourgeois stated.
“As extra adipose tissue (physique fats) decreases, the manufacturing of inflammatory cytokines reduces, resulting in a lower in systemic irritation,” she stated.
“Analysis means that power irritation might disrupt neurotransmitters like serotonin and dopamine in addition to the steadiness of intestine micro organism, probably resulting in temper imbalances.”
![Mounjaro](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/mounjaro.jpg?ve=1&tl=1)
A pharmacist holds containers of Eli Lilly & Co. Mounjaro model tirzepatide treatment at a pharmacy in Provo, Utah, on Monday, Nov. 27, 2023. (Getty Pictures)
The increase to shallowness and physique picture also can curb melancholy and anxiousness, Bourgeois famous, resulting in an general extra constructive outlook.
“People who obtain weight reduction by means of GLP-1 receptor agonists might expertise a way of accomplishment and empowerment, which might positively affect their psychological well being,” she stated.
CLICK HERE TO GET THE FOX NEWS APP
There may additionally be a “trickle-down” impact, with weight reduction usually main individuals to undertake healthier lifestyle habits — comparable to common train and improved dietary selections, the knowledgeable identified.
“These life-style modifications can have profound results on psychological well being,” she stated.
![Woman scale](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/02/1200/675/woman-scale.jpg?ve=1&tl=1)
The increase to shallowness and physique picture that comes with weight reduction also can curb melancholy and anxiousness, specialists say. (iStock)
“Bodily exercise is thought to stimulate the discharge of endorphins, which promote emotions of happiness and euphoria, and a nutrient-rich diet can present important nutritional vitamins and minerals that help mind perform and temper regulation.”
Extra analysis wanted
Whereas the Epic knowledge is “promising,” stated Bourgeois, “extra analysis is required to find out if the treatment itself is accountable for the discount in melancholy and anxiousness diagnoses.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Different components like bodily exercise, weight loss plan and sleep weren’t managed and could possibly be contributing to the mood-altering results.”
Osborn added, “I’m not saying that Ozempic will turn out to be a first-line therapy for melancholy, however it actually highlights the interconnectedness of bodily and psychological well being.”
For more Health articles, visit www.foxnews.com/health.